MCL-1/BCL-2-IN-2

• CAT Number: I017579
• CAS Number: 2163793-44-8
• Molecular Formula: C₂₀H₁₅BrN₂O₂S
• Molecular Weight: 427.31
• Purity: ≥95%
• Target: Bcl-2 Family
• IUPAC Name: 2-(2-aminoethyl)-6-(4-bromophenyl)sulfanylbenzo[de]isoquinoline-1,3-dione
• InChI: 1S/C20H15BrN2O2S/c21-12-4-6-13(7-5-12)26-17-9-8-16-18-14(17)2-1-3-15(18)19(24)23(11-10-22)20(16)25/h1-9H,10-11,22H2
• InChIKey: LPOALFWTLPKKNW-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=CC3=C2C(=C1)C(=O)N(C3=O)CCN)SC4=CC=C(C=C4)Br

MCL-1/BCL-2-IN-2 (Cat.No:I017579) is a small molecule inhibitor that targets both MCL-1 and BCL-2 proteins, which play key roles in regulating cell survival and apoptosis. By inhibiting these proteins, MCL-1/BCL-2-IN-2 promotes programmed cell death in cancer cells and shows potential as an anti-cancer therapeutic. Further studies are ongoing to explore its efficacy and safety in preclinical and clinical settings.

Reference

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.