For research use only. Not for therapeutic Use.
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].
MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].
MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1].
MCL0020 significantly reverses stress-induced anorexia in rats[1].
| Catalog Number | P000230 |
| CAS Number | 475498-26-1 |
| Synonyms | (2S)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-N-[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide |
| Molecular Formula | C34H39N7O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C34H39N7O4/c1-21(42)39-30(20-23-13-15-25-8-3-5-10-27(25)18-23)33(45)40-28(11-6-16-38-34(36)37)32(44)41-29(31(35)43)19-22-12-14-24-7-2-4-9-26(24)17-22/h2-5,7-10,12-15,17-18,28-30H,6,11,16,19-20H2,1H3,(H2,35,43)(H,39,42)(H,40,45)(H,41,44)(H4,36,37,38)/t28-,29-,30+/m0/s1 |
| InChIKey | FJFLYSMWSRRMRO-OIFRRMEBSA-N |
| SMILES | CC(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)N |
| Reference | [1]. Chaki S, et al. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003;474(1):95-101. |
