Mcl1-IN-2

• CAT Number: I003015
• CAS Number: 292057-76-2
• Molecular Formula: C19H15N3OS
• Molecular Weight: 333.41
• Purity: ≥95%
• Target: Bcl-2 Family; Bacterial
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 7-[(pyridin-2-ylamino)-thiophen-2-ylmethyl]quinolin-8-ol
• InChI: InChI=1S/C19H15N3OS/c23-19-14(9-8-13-5-3-11-21-17(13)19)18(15-6-4-12-24-15)22-16-7-1-2-10-20-16/h1-12,18,23H,(H,20,22)
• InChIKey: ICJKSTJCIAGPIS-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)NC(C2=C(C3=C(C=CC=N3)C=C2)O)C4=CC=CS4

Mcl1-IN-2（Cat No.:I003015）, is a compound developed as an inhibitor of Mcl-1, a protein crucial for cancer cell survival. By selectively targeting Mcl-1, it aims to induce apoptosis and overcome drug resistance in cancer cells. Mcl1-IN-2 shows potential as a therapeutic agent in treating various cancers.

Reference

[1]. Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.