Mcl1-IN-8

• CAT Number: I018146
• CAS Number: 678158-55-9
• Molecular Formula: C₂₂H₂₃N₃O₂S
• Molecular Weight: 393.50
• Purity: ≥95%
• Target: Bcl-2 Family
• IUPAC Name: (5Z)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-[(4-phenylphenyl)methylidene]-1,3-thiazol-4-one
• InChI: 1S/C22H23N3O2S/c26-15-14-24-10-12-25(13-11-24)22-23-21(27)20(28-22)16-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-9,16,26H,10-15H2/b20-16-
• InChIKey: IBEWMFVUBLAYJT-SILNSSARSA-N
• SMILES: C1CN(CCN1CCO)C2=NC(=O)/C(=C/C3=CC=C(C=C3)C4=CC=CC=C4)/S2

Mcl1-IN-8 (Cat.No:I018146) is a selective small molecule inhibitor targeting MCL-1, a protein that plays a crucial role in preventing apoptosis (cell death) in cancer cells. MCL-1 is overexpressed in many cancers, contributing to tumor survival and resistance to chemotherapy. Mcl1-IN-8 works by binding to MCL-1, disrupting its function and promoting programmed cell death in cancer cells. It shows potential as a therapeutic agent in treating cancers, particularly those resistant to conventional treatments. Ongoing research aims to optimize its effectiveness and safety.

Reference

[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.