Mcl1-IN-8

• CAT Number: I018146
• CAS Number: 678158-55-9
• Molecular Formula: C₂₂H₂₃N₃O₂S
• Molecular Weight: 393.5
• Purity: ≥95%
• Target: Bcl-2 Family

Mcl1-IN-8 (Cat.No:I018146) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.

Reference

[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.