For research use only. Not for therapeutic Use.
MCN-4612（Cat No.:I031663）is a selective small molecule inhibitor of the protein MCL-1 (Myeloid Cell Leukemia 1), an anti-apoptotic protein implicated in the survival of cancer cells. MCL-1 overexpression is commonly associated with various cancers, including hematological malignancies and solid tumors, contributing to chemotherapy resistance. By selectively targeting MCL-1, MCN-4612 promotes cancer cell death and sensitizes tumors to other treatments, such as chemotherapy and targeted therapies. Its development represents a promising approach to overcoming resistance in MCL-1-driven cancers and improving the efficacy of existing cancer therapies.
| Catalog Number | I031663 |
| CAS Number | 87519-84-4 |
| Synonyms | MCN 4612; MCN4612; MCN-4612 |
| Molecular Formula | C18H19N |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (6S,10bR)-6-phenyl-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline |
| InChI | InChI=1S/C18H19N/c1-2-7-14(8-3-1)17-13-19-12-6-11-18(19)16-10-5-4-9-15(16)17/h1-5,7-10,17-18H,6,11-13H2/t17-,18+/m0/s1 |
| InChIKey | KJHWRRVSXANANB-ZWKOTPCHSA-N |
| SMILES | C1C[C@@H]2C3=CC=CC=C3[C@@H](CN2C1)C4=CC=CC=C4 |
| Reference | 1. Nielsen JA, Duda NJ, Mokler DJ, Moore KE. Self-administration of central stimulants by rats: a comparison of the effects of d-amphetamine, methylphenidate and McNeil 4612. Pharmacol Biochem Behav. 1984 Feb;20(2):227-32. doi: 10.1016/0091-3057(84)90247-8. PMID: 6144109. |
