MCU-i4

For research use only. Not for therapeutic Use.

  • CAT Number: I031690
  • CAS Number: 371924-24-2
  • Molecular Formula: C23H27N3O2
  • Molecular Weight: 377.488
  • Purity: 98%
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MCU-i4 (CAT: I031690) is a novel compound that functions as a negative modulator of the mitochondrial calcium uniporter (MCU). It acts by binding to MICU1, a regulatory subunit of the MCU complex, and disrupting its normal function. By impairing the activity of the MCU, MCU-i4 interferes with the transport of calcium ions into the mitochondria. This disruption of calcium homeostasis has been shown to affect muscle cell growth.


Catalog Number I031690
CAS Number 371924-24-2
Synonyms

MCU-i4; MCUi4; MCU i4;

Molecular Formula C23H27N3O2
Purity 98%
Target Mitochondrial Metabolism
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
InChI InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H,5-7H2,1-4H3,(H,24,25)
InChIKey RIWXBJCWHVMATR-UHFFFAOYSA-N
SMILES O=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC
Reference

1: Di Marco G, Vallese F, Jourde B, Bergsdorf C, Sturlese M, De Mario A, Techer- Etienne V, Haasen D, Oberhauser B, Schleeger S, Minetti G, Moro S, Rizzuto R, De Stefani D, Fornaro M, Mammucari C. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. doi: 10.1016/j.celrep.2020.01.081. PMID: 32075766; PMCID: PMC7034061.

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