For research use only. Not for therapeutic Use.
MCUF-651 is a selective and orally bioavailable PAM of guanylyl cyclase A receptor (GC-A) with an EC50 value of 0.45 µM in HEK293 GC-A cells. MCUF-651 exhibits therapeutic activity in human hypertension and heart failure ex vivo.
Keywords: MCUF-651 | Supplier | GC-A PAM | MCUF651 | MCUF 651 | CAS [2747162-85-0] | Atrial natriuretic peptide (ANP) | Guanylate cyclase | PAM | Enzymes | Cardiovascular disease | Hypertension | Heart failure | GC-A/cGMP signaling pathway | NPR1 | GUCY2A
| Catalog Number | I047682 |
| CAS Number | 2747162-85-0 |
| Molecular Formula | C17H22F2N4OS |
| Purity | ≥95% |
| IUPAC Name | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-1-[2-(dimethylamino)ethyl]piperidine-3-carboxamide |
| InChI | InChI=1S/C17H22F2N4OS/c1-22(2)6-7-23-5-3-4-11(10-23)16(24)21-17-20-15-13(19)8-12(18)9-14(15)25-17/h8-9,11H,3-7,10H2,1-2H3,(H,20,21,24) |
| SMILES | CN(C)CCN1CCCC(C1)C(=O)NC2=NC3=C(C=C(C=C3S2)F)F |
| Reference | SJ Sangaralingham et al. Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2109386118. |
