For research use only. Not for therapeutic Use.
MD-222 (Cat No.: I031695) is a potent and selective inhibitor of MDM2, a key negative regulator of the tumor suppressor protein p53. By blocking the MDM2-p53 interaction, MD-222 restores p53 activity, leading to cell cycle arrest and apoptosis in p53-proficient cancer cells. It has shown promise in preclinical studies for targeting malignancies with overexpressed MDM2. MD-222 is widely utilized in oncology research to explore therapeutic strategies for restoring p53 function, offering significant potential for advancing cancer treatments and precision medicine.
| CAS Number | 2136246-72-3 |
| Synonyms | MD-222; MD222; MD 222; |
| Molecular Formula | C48H47Cl2FN6O6 |
| Purity | 98% |
| Target | PROTAC |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
| IUPAC Name | (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide |
| InChI | InChI=1S/C48H47Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-6,9,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1 |
| InChIKey | RRSNDVCODIMOFX-MPKOGUQCSA-N |
| SMILES | O=C([C@H](N1)[C@H](C2=CC=CC(Cl)=C2F)[C@]3(C(NC4=C3C=CC(Cl)=C4)=O)C51CCCCC5)NC6=CC=C(C(NCCCCCC7=CC=CC8=C7CN(C(CC9)C(NC9=O)=O)C8=O)=O)C=C6 |
