MD-222

• CAT Number: I031695
• CAS Number: 2136246-72-3
• Molecular Formula: C48H47Cl2FN6O6
• Molecular Weight: 893.8384
• Purity: 98%
• Synonyms: MD-222; MD222; MD 222
• Target: PROTAC
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
• IUPAC Name: (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide
• InChI: InChI=1S/C48H47Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-6,9,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1
• InChIKey: RRSNDVCODIMOFX-MPKOGUQCSA-N
• SMILES: O=C([C@H](N1)[C@H](C2=CC=CC(Cl)=C2F)[C@]3(C(NC4=C3C=CC(Cl)=C4)=O)C51CCCCC5)NC6=CC=C(C(NCCCCCC7=CC=CC8=C7CN(C(CC9)C(NC9=O)=O)C8=O)=O)C=C6

MD-222 is a potent and selective inhibitor of MDM2, a key negative regulator of the tumor suppressor protein p53. By blocking the MDM2-p53 interaction, MD-222 restores p53 activity, leading to cell cycle arrest and apoptosis in p53-proficient cancer cells. It has shown promise in preclinical studies for targeting malignancies with overexpressed MDM2. MD-222 is widely utilized in oncology research to explore therapeutic strategies for restoring p53 function, offering significant potential for advancing cancer treatments and precision medicine.