MD 780236

• CAT Number: I031703
• CAS Number: 73423-36-6
• Molecular Formula: C18H19ClN2O3
• Molecular Weight: 346.811
• Purity: 98%
• Synonyms: MD 780236; MD780236; MD-780236
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-Oxazolidinone, 3-(4-((3-chlorophenyl)methoxy)phenyl)-5-((methylamino)methyl)-
• InChI: InChI=1S/C18H19ClN2O3/c1-20-10-17-11-21(18(22)24-17)15-5-7-16(8-6-15)23-12-13-3-2-4-14(19)9-13/h2-9,17,20H,10-12H2,1H3
• InChIKey: KYXSTSXVEXKFJI-UHFFFAOYSA-N
• SMILES: O=C1OC(CNC)CN1C2=CC=C(OCC3=CC=CC(Cl)=C3)C=C2

MD 780236 is a monoamine oxidase-B inhibitor.

Reference

1: Tipton KF, Fowler CJ, McCrodden JM, Strolin Benedetti M. The enzyme-activated irreversible inhibition of type-B monoamine oxidase by 3-(4-[(3-chlorophenyl)methoxy]phenyl)-5-[(methylamino) methyl]-2-oxazolidinone methanesulphonate (compound MD 780236) and the enzyme-catalysed oxidation of this compound as competing reactions. Biochem J. 1983 Jan 1;209(1):235-42. PubMed PMID: 6847610; PubMed Central PMCID: PMC1154077.
2: Strolin Benedetti M, Dow J. A monoamine oxidase-B inhibitor, MD 780236, metabolized essentially by the A form of the enzyme in the rat. J Pharm Pharmacol. 1983 Apr;35(4):238-45. PubMed PMID: 6133934.
3: Dostert P, Guffroy C, Strolin Benedetti M, Boucher T. Inhibition of semicarbazide-sensitive amine oxidase by monoamine oxidase B inhibitors from the oxazolidinone series. J Pharm Pharmacol. 1984 Nov;36(11):782-5. PubMed PMID: 6150988.
4: Tipton KF, McCrodden JM, Henehan GT, Boucher T, Fowler CJ. The formation of the acidic and alcoholic metabolites of MD 780236. Biochem Pharmacol. 1984 Apr 15;33(8):1377-8. PubMed PMID: 6370268.
5: Dostert P, Strolin Benedetti M, Guffroy C. Different stereoselective inhibition of monoamine oxidase-B by the R- and S-enantiomers of MD 780236. J Pharm Pharmacol. 1983 Mar;35(3):161-5. PubMed PMID: 6132973.
6: Strolin Benedetti M, Dow J, Boucher T, Dostert P. Metabolism of the monoamine oxidase-B inhibitor, MD 780236 and its enantiomers by the A and B forms of the enzyme in the rat. J Pharm Pharmacol. 1983 Dec;35(12):837-40. PubMed PMID: 6141254.
7: Kinemuchi H, Morikawa F, Ueda T, Arai Y. Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. I. Inhibition by a selective monoamine oxidase-B inhibitor, MD 780236. Jpn J Pharmacol. 1986 Jun;41(2):183-9. PubMed PMID: 3747265.
8: Fuller RW, Wong CJ, Hemrick-Luecke SK. MD 240928 and harmaline: opposite selectivity in antagonism of the inactivation of types A and B monoamine oxidase by pargyline in mice. Life Sci. 1986 Feb 3;38(5):409-12. PubMed PMID: 3945167.
9: Fuller RW, Hemrick-Luecke SK. Influence of selective, reversible inhibitors of monoamine oxidase on the prolonged depletion of striatal dopamine by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Life Sci. 1985 Sep 23;37(12):1089-96. PubMed PMID: 3875779.
10: Turkish S, Yu PH, Greenshaw AJ. Monoamine oxidase-B inhibition: a comparison of in vivo and ex vivo measures of reversible effects. J Neural Transm. 1988;74(3):141-8. PubMed PMID: 3145323.
11: Benedetti MS, Dostert P, Guffroy C, Tipton KF. Partial or total protection from long-acting monoamine oxidase inhibitors (MAOIs) by new short-acting MAOIs of type A MD780515 and type B MD780236. Mod Probl Pharmacopsychiatry. 1983;19:82-104. PubMed PMID: 6408412.
12: Ding CZ, Silverman RB. Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation. J Med Chem. 1993 Nov 12;36(23):3606-10. PubMed PMID: 8246228.