For research use only. Not for therapeutic Use.
MDK-7933, also known as HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). MDK-7933 was first reported in ChemMedChem. 2012 Oct;7(10):1815-24. MDK-7933 has CAS#1417997-93-3.
| Catalog Number | I014461 |
| CAS Number | 1417997-93-3 |
| Synonyms | HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933.;(E)-N-hydroxy-3-(5-methoxy-[1,1′:4′,1”-terphenyl]-2-yl)acrylamide |
| Molecular Formula | C22H19NO3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C22H19NO3/c1-26-20-13-11-19(12-14-22(24)23-25)21(15-20)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15,25H,1H3,(H,23,24)/b14-12+ |
| InChIKey | ASHPRZYGCOMVHO-WYMLVPIESA-N |
| SMILES | ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O |
| Reference | </br>[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.</br> |
