MDK0734

• CAT Number: I031736
• CAS Number: 1366240-73-4
• Molecular Formula: C15H17N3O2
• Molecular Weight: 271.32
• Purity: 98%
• Synonyms: Cathepsin B Inhinitor-42
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 8-(4-Methylpiperidin-1-yl)-5-nitroquinoline
• InChI: InChI=1S/C15H17N3O2/c1-11-6-9-17(10-7-11)14-5-4-13(18(19)20)12-3-2-8-16-15(12)14/h2-5,8,11H,6-7,9-10H2,1H3
• InChIKey: ABDSNJJYMMKJBF-UHFFFAOYSA-N
• SMILES: O=[N+](C1=C2C=CC=NC2=C(N3CCC(C)CC3)C=C1)[O-]

MDK0734(CAT: I031736) is a potent and selective inhibitor of checkpoint kinase 1 (CHK1), widely utilized in oncology research. By targeting CHK1, it disrupts DNA damage response pathways, impairing cancer cells’ ability to repair DNA damage and enhancing their sensitivity to DNA-damaging agents such as chemotherapy and radiation. MDK0734 is particularly valuable for studying therapeutic strategies that exploit cancer-specific vulnerabilities in cell cycle regulation and genomic stability. Its high specificity and efficacy make it a critical tool for preclinical research aimed at developing targeted therapies for cancers reliant on CHK1-mediated DNA repair mechanisms.