For research use only. Not for therapeutic Use.
MDK4882 (CAT: I011952) is a compound that exhibits potent PKM2 inhibitory activity, surpassing the activity of the well-known PKM2 inhibitor shikonin. It has demonstrated nanomolar antiproliferative activity against various cancer cell lines, particularly those with high expression of PKM2, such as HCT116, Hela, and H1299 cells. The specific mechanism of action and target of MDK4882 are not mentioned in the available information. However, its ability to inhibit PKM2 and exert antiproliferative effects on cancer cells suggests its potential as a therapeutic agent for cancer treatment.
| Catalog Number | I011952 |
| CAS Number | 94164-88-2 |
| Synonyms | PKM2 inhibitor; MDK4882; MDK-4882; MD K4882.compound 3k;(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate |
| Molecular Formula | C18H19NO2S2 |
| Purity | ≥95% |
| Target | Pyruvate Kinase |
| Solubility | Soluble in DMSO |
| Storage | Store at 0-8 °C |
| IUPAC Name | (3-methyl-1,4-dioxonaphthalen-2-yl)methyl piperidine-1-carbodithioate |
| InChI | InChI=1S/C18H19NO2S2/c1-12-15(11-23-18(22)19-9-5-2-6-10-19)17(21)14-8-4-3-7-13(14)16(12)20/h3-4,7-8H,2,5-6,9-11H2,1H3 |
| InChIKey | STAFOGVMELKGRI-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)C2=CC=CC=C2C1=O)CSC(=S)N3CCCCC3 |
| Reference | </br>1: Ning X, Qi H, Li R, Li Y, Jin Y, McNutt MA, Liu J, Yin Y. Discovery of novel</br> naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of</br> pyruvate kinase. Eur J Med Chem. 2017 Sep 29;138:343-352. doi:</br> 10.1016/j.ejmech.2017.06.064. Epub 2017 Jun 29. PubMed PMID: 28688274.</br> </br> |
