MDL-28133A

• CAT Number: I031795
• CAS Number: 136861-96-6
• Molecular Formula: C21H24ClFN2O4S
• Molecular Weight: 454.94
• Purity: 98%
• Synonyms: MDL 28133A; MDL-28133A; MDL28133A
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[4-[1-[2-(4-fluorophenyl)-2-oxoethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide;hydrochloride
• InChI: InChI=1S/C21H23FN2O4S.ClH/c1-29(27,28)23-19-8-4-16(5-9-19)21(26)17-10-12-24(13-11-17)14-20(25)15-2-6-18(22)7-3-15;/h2-9,17,23H,10-14H2,1H3;1H
• InChIKey: YVIOSUWCZDHHEI-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)NC1=CC=C(C=C1)C(=O)C2CCN(CC2)CC(=O)C3=CC=C(C=C3)F.Cl

MDL-28133A（Cat No.:I031795）is a selective small molecule inhibitor of phospholipase A2 (PLA2), an enzyme involved in the release of arachidonic acid from phospholipids, which is a precursor for inflammatory mediators like prostaglandins and leukotrienes. By inhibiting PLA2, MDL-28133A has potential therapeutic applications in treating inflammatory conditions, such as arthritis, asthma, and cardiovascular diseases. It may also have neuroprotective effects in diseases where inflammation plays a central role. Preclinical studies have shown promise, but further research is needed to assess the compound’s safety, efficacy, and clinical applications in inflammatory and autoimmune disorders.

Reference

1. Hsieh CP, Sakai K, Bruns GC, Dage RC. Effects of MDL 28,133A, a 5-HT2 receptor antagonist, on platelet aggregation and coronary thrombosis in dogs. J Cardiovasc Pharmacol. 1994 Nov;24(5):761-72. doi: 10.1097/00005344-199424050-00011. PMID: 7532754.
2. Schmidt CJ, Black CK, Taylor VL, Fadayel GM, Humphreys TM, Nieduzak TR, Sorensen SM. The 5-HT2 receptor antagonist, MDL 28,133A, disrupts the serotonergic-dopaminergic interaction mediating the neurochemical effects of 3,4-methylenedioxymethamphetamine. Eur J Pharmacol. 1992 Sep 22;220(2-3):151-9. doi: 10.1016/0014-2999(92)90743-n. PMID: 1425989.
3. Feldman DJ, Frank RA, Kehne JH, Flannery R, Brown D, Soni S, Byrd G, Shah S. Mixed D2/5-HT2 antagonism differentially affects apomorphine- and amphetamine-induced stereotyped behavior. Pharmacol Biochem Behav. 1997 Oct;58(2):565-72. doi: 10.1016/s0091-3057(97)00292-x. PMID: 9300620.