MDL-28133A

• CAT Number: I031795
• CAS Number: 136861-96-6
• Molecular Formula: C21H24ClFN2O4S
• Molecular Weight: 454.94
• Purity: 98%
• Synonyms: MDL 28133A; MDL-28133A; MDL28133A
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Methanesulfonamide, N-(4-((1-(2-(4-fluorophenyl)-2-oxoethyl)-4-piperidinyl)carbonyl)phenyl)-, monohydrochloride
• InChI: InChI=1S/C21H23FN2O4S.ClH/c1-29(27,28)23-19-8-4-16(5-9-19)21(26)17-10-12-24(13-11-17)14-20(25)15-2-6-18(22)7-3-15;/h2-9,17,23H,10-14H2,1H3;1H
• InChIKey: YVIOSUWCZDHHEI-UHFFFAOYSA-N
• SMILES: Cl.CS(=O)(=O)Nc1ccc(cc1)C(=O)C2CCN(CC(=O)c3ccc(F)cc3)CC2

MDL-28133A is a 5-HT2 receptor antagonist.

Reference

1. Hsieh CP, Sakai K, Bruns GC, Dage RC. Effects of MDL 28,133A, a 5-HT2 receptor antagonist, on platelet aggregation and coronary thrombosis in dogs. J Cardiovasc Pharmacol. 1994 Nov;24(5):761-72. doi: 10.1097/00005344-199424050-00011. PMID: 7532754.
2. Schmidt CJ, Black CK, Taylor VL, Fadayel GM, Humphreys TM, Nieduzak TR, Sorensen SM. The 5-HT2 receptor antagonist, MDL 28,133A, disrupts the serotonergic-dopaminergic interaction mediating the neurochemical effects of 3,4-methylenedioxymethamphetamine. Eur J Pharmacol. 1992 Sep 22;220(2-3):151-9. doi: 10.1016/0014-2999(92)90743-n. PMID: 1425989.
3. Feldman DJ, Frank RA, Kehne JH, Flannery R, Brown D, Soni S, Byrd G, Shah S. Mixed D2/5-HT2 antagonism differentially affects apomorphine- and amphetamine-induced stereotyped behavior. Pharmacol Biochem Behav. 1997 Oct;58(2):565-72. doi: 10.1016/s0091-3057(97)00292-x. PMID: 9300620.