MDL-29951

• CAT Number: I001176
• CAS Number: 130798-51-5
• Molecular Formula: C12H9Cl2NO4
• Molecular Weight: 302.107
• Purity: ≥95%
• Synonyms: 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
• Target: NMDA Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 0.14 mM ([3H]glycine binding) [1].
• InChI: InChI=1S/C12H9Cl2NO4/c13-5-3-7(14)10-6(1-2-9(16)17)11(12(18)19)15-8(10)4-5/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
• InChIKey: KNBSYZNKEAWABY-UHFFFAOYSA-N
• SMILES: C1=C(C=C2C(=C1Cl)C(=C(N2)C(=O)O)CCC(=O)O)Cl

MDL-29951 (CAT: I001176) is a novel compound that acts as a glycine antagonist of NMDA (N-methyl-D-aspartate) receptor activation. NMDA receptors play a crucial role in excitatory neurotransmission and synaptic plasticity in the central nervous system. By acting as a glycine antagonist, MDL-29951 modulates the activity of NMDA receptors and inhibits their activation by glycine, thereby altering the transmission of excitatory signals. This mechanism of action suggests potential applications for MDL-29951 in the modulation of NMDA receptor-mediated processes, such as neuronal communication, synaptic plasticity, and neurophysiological functions in various neurological and psychiatric disorders.

Reference

[1]. Baron BM, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56.

[2]. Wright SW, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8.

[3]. Harden TK. Enigmatic GPCR finds a stimulating drug. Sci Signal. 2013 Oct 22;6(298):pe34.