MDL-800

• CAT Number: I031820
• CAS Number: 2275619-53-7
• Molecular Formula: C21H16BrCl2FN2O6S2
• Molecular Weight: 626.3
• Purity: ≥95%

MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 µM.

Reference

[1] Huang Z, et al. Nat Chem Biol. 2018 Dec;14(12):1118-1126.
[2] He T, et al. Acta Pharm Sin B. 2021 Mar; 11(3): 708–726.