MDM2-IN-1

• CAT Number: I017376
• CAS Number: 1410737-09-5
• Molecular Formula: C₂₃H₂₁Cl₂FN₂O₃
• Molecular Weight: 463.33
• Purity: ≥95%
• Target: MDM-2/p53
• Storage: 4°C, protect from light
• InChI: InChI=1S/C23H21Cl2FN2O3/c24-12-7-8-14-16(11-12)27-21(31)23(14)17(13-5-4-6-15(25)18(13)26)19(20(29)30)28-22(23)9-2-1-3-10-22/h4-8,11,17,19,28H,1-3,9-10H2,(H,27,31)(H,29,30)/t17-,19+,23+/m0/s1
• InChIKey: GQQZEPFAYBPYQU-GEQKSPFYSA-N
• SMILES: C1CCC2(CC1)C3(C(C(N2)C(=O)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC3=O

MDM2-IN-1 (Cat No.:I017376) is a small molecule inhibitor of the MDM2-p53 interaction, which is a key regulator of cell cycle progression and apoptosis. By inhibiting this interaction, MDM2-IN-1 can stabilize and activate p53, resulting in the induction of cell cycle arrest and apoptosis in cancer cells. MDM2-IN-1 has demonstrated potent antitumor activity in various cancer cell lines and animal models and is being investigated as a potential cancer therapeutic agent.

Reference

[1]. Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98.