ME-1111

• CAT Number: I007938
• CAS Number: 1391758-52-3
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.26
• Purity: ≥95%
• Synonyms: ME-1111; ME 1111; ME1111.;2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol
• Target: Fungal
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 2-(3,5-dimethylpyrazol-1-yl)-5-methylphenol
• InChI: InChI=1S/C12H14N2O/c1-8-4-5-11(12(15)6-8)14-10(3)7-9(2)13-14/h4-7,15H,1-3H3
• InChIKey: VQXHPRBERPTLQW-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)N2C(=CC(=N2)C)C)O

ME-1111（Cat No.:I007938）is a small-molecule compound under investigation for its potential therapeutic applications in cancer treatment. It is a selective inhibitor of the protein methyltransferase PRMT5 (protein arginine methyltransferase 5), which plays a crucial role in regulating gene expression, RNA splicing, and cell survival. Overexpression of PRMT5 has been linked to various cancers, including lymphomas and solid tumors. By inhibiting PRMT5, ME-1111 disrupts these critical cellular processes, leading to impaired tumor cell growth and increased apoptosis. ME-1111 is currently being evaluated in preclinical and clinical trials for its efficacy in oncology.