Mebendazole

For research use only. Not for therapeutic Use.

  • CAT Number: A000053
  • CAS Number: 31431-39-7
  • Molecular Formula: C16H13N3O3
  • Molecular Weight: 295.30
  • Purity: ≥95%
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Mebendazole(Cat No.:A000053)is a broad-spectrum anthelmintic medication widely used to treat parasitic worm infections, including those caused by roundworms, whipworms, hookworms, and tapeworms. It works by inhibiting microtubule formation in the parasite’s cells, disrupting glucose uptake and leading to energy depletion and death. Mebendazole is effective in single or multiple-dose regimens and is well-tolerated with minimal side effects. Its broad efficacy and safety profile make it a key tool in managing helminth infections, improving public health, and supporting deworming programs in endemic regions.


Catalog Number A000053
CAS Number 31431-39-7
Synonyms

Vermox, Telmin, Pantelmin, Mebenvet

Molecular Formula C16H13N3O3
Purity ≥95%
Target Microtubule/Tubulin
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate
InChI InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
InChIKey OPXLLQIJSORQAM-UHFFFAOYSA-N
SMILES COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3
Reference

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Safety of a Single-Dose Mebendazole 500 mg Chewable, Rapidly-Disintegrating
Tablet for Ascaris Lumbricoides and Trichuris Trichiura Infection Treatment in
Pediatric Patients: A Double-Blind, Randomized, Placebo-Controlled, Phase 3
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2: Yang CA, Liang C, Lin CL, Hsiao CT, Peng CT, Lin HC, Chang JG. Impact of
Enterobius vermicularis infection and mebendazole treatment on intestinal
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Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant
gliomas. Invest New Drugs. 2017 Aug 29. doi: 10.1007/s10637-017-0503-7. [Epub
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5: Mrus J, Baeten B, Engelen M, Silber SA. Efficacy of single-dose 500 mg
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Andersson C, Loskog A, Frykn&#228;s M, Nygren P, Larsson R. The anticancer effect of
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Del Poeta M, Vainstein MH, Rodrigues ML. The Anti-helminthic Compound Mebendazole
Has Multiple Antifungal Effects against Cryptococcus neoformans. Front Microbiol.
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10: De Witt M, Gamble A, Hanson D, Markowitz D, Powell C, Al Dimassi S, Atlas M,
Boockvar J, Ruggieri R, Symons M. Repurposing Mebendazole as a Replacement for
Vincristine for the Treatment of Brain Tumors. Mol Med. 2017 Apr 5;23. doi:
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