For research use only. Not for therapeutic Use.
<p>a voltage-dependent and GABA-gated Cl- channels blocker; non-competitive GABA antagonist.</p><br />Organophosphorous compound<!–C<SUB>5</SUB>H<SUB>9</SUB>O<SUB>4</SUB>P–>, synthetic.</br><p>Cl- channel blocking concentration: IC<sub>100</sub> = 500 nM (Lymnaea stagnalis);<br /> experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Mebicyphat up to 10 �M.</p></br>
| Catalog Number | M048382 |
| CAS Number | 1449-89-4 |
| Molecular Formula | C5H9O4P |
| Purity | ≥95% |
| Storage | Desiccate at +4C |
| IUPAC Name | 4-methyl-2,6,7-trioxa-1$l^{5} |
| InChI | InChI=1S/C5H9O4P/c1-5-2-7-10(6,8-3-5)9-4-5/h2-4H2,1H3 |
| InChIKey | SEOXVQTUPVKLTH-UHFFFAOYSA-N |
| SMILES | CC12COP(=O)(OC1)OC2 |
| Reference | – Bellet E. M., Casida J. E., Sciences (1973). 182:1135-1136<br /><br />- Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212<br /><br />- V. I. Fetisov et al., Biol. Membr.(1986) (Russian). 3(5):968-970<br /><br />- Squires R. F. et al., Mol. Pharmacol. (1983). 23:326-331<br /><br /><br /><br /> |
