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55-86-7-Mechlorethamine Hydrochloride Mechlorethamine Hydrochloride

Mechlorethamine Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000177
  • CAS Number: 55-86-7
  • Molecular Formula: C5H11Cl2N.HCl
  • Molecular Weight: 192.51
  • Purity: ≥95%
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Related Small Molecules: Retapamulin     Fenbendazole     tert-Butyl Bromoacetate    

Mechlorethamine, an antineoplastic nitrogen mustard also known as HN2 hydrochloride, is a nitrogen analog of sulfur mustard. It is a light yellow brown, crystalline, hygroscopic powder that is very soluble in water and also soluble in alcohol. (Source: http://www.rxlist.com/mustargen-drug.htm).


Catalog Number A000177
CAS Number 55-86-7
Synonyms

55-86-7; Chlormethine hydrochloride; Chlorethamine; Mechlorethamine HCl; Chlormethinum

Molecular Formula C5H11Cl2N.HCl
Purity ≥95%
Target DNA synthesis
Storage -20°C
InChI 1S/C5H11Cl2N.ClH/c1-8(4-2-6)5-3-7;/h2-5H2,1H3;1H
InChIKey QZIQJVCYUQZDIR-UHFFFAOYSA-N
SMILES CN(CCCl)CCCl.Cl
Reference

1: Vonderheid EC, Ekbote SK, Kerrigan K, Kalmanson JD, Van Scott EJ, Rook AH,
Abrams JT. The prognostic significance of delayed hypersensitivity to
dinitrochlorobenzene and mechlorethamine hydrochloride in cutaneous T cell
lymphoma. J Invest Dermatol. 1998 Jun;110(6):946-50. PubMed PMID: 9620303.
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2: Zhang Y, Trissel LA, Johansen JF, Kimball CL. Stability of mechlorethamine
hydrochloride 0.01% ointment in aquaphor base. Int J Pharm Compd. 1998
Jan-Feb;2(1):89-91. PubMed PMID: 23989487.

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3: Cummings J, MacLellan A, Langdon SJ, Smyth JF. The long term stability of
mechlorethamine hydrochloride (nitrogen mustard) ointment measured by HPLC. J
Pharm Pharmacol. 1993 Jan;45(1):6-9. PubMed PMID: 8094449.
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4: Turczan J, Lau-Cam C. Proton magnetic resonance (PMR) spectroscopic
determination of mechlorethamine hydrochloride for injection in commercial unit
doses. Pharmazie. 1986 Nov;41(11):775-6. PubMed PMID: 3562509.
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5: Taylor JR, Halprin KM, Levine V, Aoyagi T. Mechlorethamine hydrochloride
solutions and ointment. Prolonged stability and biological activity. Arch
Dermatol. 1980 Jul;116(7):783-5. PubMed PMID: 7396542.
<br>

6: Leshaw S, Simon RS, Bear RL. Failure to induce tolerance to mechlorethamine
hydrochloride. Arch Dermatol. 1977 Oct;113(10):1406-8. PubMed PMID: 911169.
<br>

7: Clough JD. Acute systemic lupus erythematosus in IgA deficiency.
Mechlorethamine hydrochloride therapy. Cleve Clin Q. 1975 Winter;42(4):327-34.
PubMed PMID: 1082387.

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8: Van Scott EJ. Complete regressions of mycosis fungoides with topical
mechlorethamine hydrochloride. JAMA. 1972 Nov 27;222(9):1172. PubMed PMID:
4678061.
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9: Papp RH, Hawkins HB, Share NN, Wang SC. Emesis induced by the
intracerebroventricular administration of hydergine and mechlorethamine
hydrochloride. J Pharmacol Exp Ther. 1966 Nov;154(2):333-8. PubMed PMID: 4958820.

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10: CAMPBELL WG Jr, BERRY SR. LESIONS IN SUBSYNOVIAL TISSUE. CHANGES IN RABBITS
AFTER INTRA-ARTICULAR INJECTIONS OF MECHLORETHAMINE HYDROCHLORIDE ALONE AND
TOGETHER WITH AN ADRENOCORTICAL STEROID. Arch Pathol. 1965 Jan;79:7-13. PubMed
PMID: 14226032.

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