For research use only. Not for therapeutic Use.
Meclizine hydrochloride is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. Meclizine hydrochloride increases human pregnane X receptor (hPXR) target gene expression in human hepatocyte primary cultures.
| Catalog Number | A000946 |
| CAS Number | 1104-22-9 |
| Synonyms | NSC 28728 |
| Molecular Formula | C25H27ClN2 • 2HCl |
| Purity | ≥95% |
| Target | Histamine H1 Antagonist |
| Storage | 3 years -20C powder |
| InChIKey | VCTHNOIYJIXQLV-UHFFFAOYSA-N |
| Reference | </br>1: Zhao Y, Quan P, Fang L. Preparation of an oral thin film containing meclizine </br> hydrochloride: In vitro and in vivo evaluation. Int J Pharm. 2015 Dec</br> 30;496(2):314-22. doi: 10.1016/j.ijpharm.2015.10.008. Epub 2015 Oct 9. PubMed</br> PMID: 26456247.</br>2: Peraman R, Manikala M, Kondreddy VK, Yiragamreddy PR. A stability-indicating</br> RP-HPLC method for the quantitative analysis of meclizine hydrochloride in tablet</br> dosage form. J Chromatogr Sci. 2015 May-Jun;53(5):793-9. doi:</br> 10.1093/chromsci/bmu127. Epub 2015 Feb 1. PubMed PMID: 25644814.</br>3: Mirza T, Lunn MJ, Keeley FJ, George RC, Bodenmiller JR. Cleaning level</br> acceptance criteria and a high pressure liquid chromatography procedure for the</br> assay of Meclizine Hydrochloride residue in swabs collected from pharmaceutical</br> manufacturing equipment surfaces. J Pharm Biomed Anal. 1999 Apr;19(5):747-56.</br> PubMed PMID: 10698538.</br>4: Wong CK, Urbigkit JR, Conca N, Cohen DM, Munnelly KP. GLC determination of</br> meclizine hydrochloride in tablet formulations. J Pharm Sci. 1973</br> Aug;62(8):1340-2. PubMed PMID: 4733473.</br>5: Grumpelt HR, Maddex BE, Nebus EJ, Rattner JC. Effects of diazepam and</br> meclizine hydrochloride on emotional upset due to perceptual dissonance and</br> motion. Percept Mot Skills. 1971 Jun;32(3):753-4. PubMed PMID: 5104948.</br>6: KENDRICK FJ, KING CT. ORAL ANOMALIES INDUCED IN THE RAT BY MECLIZINE</br> HYDROCHLORIDE. Oral Surg Oral Med Oral Pathol. 1964 Nov;18:690-6. PubMed PMID:</br> 14199585.</br>7: KENDRICK FJ, WEAVER SA. ALTERATION IN AMNIOTIC FLUID VOLUME AND OTHER FINDINGS</br> IN MECLIZINE HYDROCHLORIDE INDUCED ANOMALIES. Proc Soc Exp Biol Med. 1963</br> Dec;114:747-50. PubMed PMID: 14120339.</br>8: LOOMIS GR. Evaluation of meclizine hydrochloride in prevention of seasickness.</br> Mil Med. 1955 Jul;117(1):51-3. PubMed PMID: 14393609.</br>9: Hom FS, Ebert WR. Determination of meclizine hydrochloride by ion-pair</br> extraction with methyl orange. J Pharm Sci. 1977 May;66(5):710-3. PubMed PMID:</br> 17714.</br>10: Martin N, Oosterveld WJ. The vestibular effects of meclizine</br> hydrochloride-niacin combination (Antivert). Acta Otolaryngol. 1970</br> Jul;70(1):6-9. PubMed PMID: 5311676.</br>11: Kutscher AH, Zegarelli EV, Hyman GA, Tovell HM. A case report: prolonged use </br> of meclizine hydrochloride with total absence of side effects. Ann Allergy. 1966 </br> May;24(5):246-7. PubMed PMID: 5937178.</br>12: KING CT. Teratogenic effects of meclizine hydrochloride on the rat. Science. </br> 1963 Jul 26;141(3578):353-5. PubMed PMID: 14032825.</br>13: GUTNER LB, GOULD WJ, HANLEY JW. Effect of meclizine hydrochloride (bonamine) </br> upon vestibular function; observations with notes on its value in comparison with</br> cyclizine hydrochloride (marezine) and dimenhydrinate (dramamine). AMA Arch</br> Otolaryngol. 1955 Nov;62(5):497-503. PubMed PMID: 13268159.</br></br> |
