Mefenamic Acid

For research use only. Not for therapeutic Use.

  • CAT Number: A000775
  • CAS Number: 61-68-7
  • Molecular Formula: C15H15NO2
  • Molecular Weight: 241.29
  • Purity: ≥95%
Inquiry Now

Mefenamic Acid is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase and has demonstrated antiproliferative activity against colorectal cancer cells.


Catalog Number A000775
CAS Number 61-68-7
Synonyms

61-68-7; Ponstel; Ponstan; 2-[(2,3-dimethylphenyl)amino]benzoic acid; Mephenamic acid

Molecular Formula C15H15NO2
Purity ≥95%
Target COX
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
InChIKey HYYBABOKPJLUIN-UHFFFAOYSA-N
SMILES CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C
Reference

1: Kaosombatwattana U, Limsrivilai J, Pongpaibul A, Maneerattanaporn M,
Charatcharoenwitthaya P. Severe enteropathy with villous atrophy in prolonged
mefenamic acid users – a currently under-recognized in previously well-recognized
complication: Case report and review of literature. Medicine (Baltimore). 2017
Nov;96(44):e8445. doi: 10.1097/MD.0000000000008445. Review. PubMed PMID:
29095288.
<br>

2: Jarrar QB, Hakim MN, Cheema MS, Zakaria ZA. Comparative ultrastructural
hepatic alterations induced by free and liposome-encapsulated mefenamic acid.
Ultrastruct Pathol. 2017 Sep-Oct;41(5):335-345. doi:
10.1080/01913123.2017.1349850. PubMed PMID: 28829237.

<br>
3: Alshehri S, Shakeel F, Ibrahim M, Elzayat E, Altamimi M, Shazly G, Mohsin K,
Alkholief M, Alsulays B, Alshetaili A, Alshahrani A, Almalki B, Alanazi F.
Influence of the microwave technology on solid dispersions of mefenamic acid and
flufenamic acid. PLoS One. 2017 Jul 31;12(7):e0182011. doi:
10.1371/journal.pone.0182011. eCollection 2017. PubMed PMID: 28759638; PubMed
Central PMCID: PMC5536357.
<br>

4: Amiri Farahani &#203;L, Hasanpoor-Azghdy SB, Kasraei H, Heidari T. Comparison of
the effect of honey and mefenamic acid on the severity of pain in women with
primary dysmenorrhea. Arch Gynecol Obstet. 2017 Aug;296(2):277-283. doi:
10.1007/s00404-017-4409-6. Epub 2017 Jun 16. PubMed PMID: 28623433.
<br>

5: Abbas N, Oswald IDH, Pulham CR. Accessing Mefenamic Acid Form II through
High-Pressure Recrystallisation. Pharmaceutics. 2017 May 16;9(2). pii: E16. doi:
10.3390/pharmaceutics9020016. PubMed PMID: 28509850; PubMed Central PMCID:
PMC5489933.
<br>

6: Morcoss MM, Abdelwahab NS, Ali NW, Elsaady MT. Different Chromatographic
Methods for Simultaneous Determination of Mefenamic Acid and Two of Its Toxic
Impurities. J Chromatogr Sci. 2017 Aug 1;55(7):766-772. doi:
10.1093/chromsci/bmx034. PubMed PMID: 28498911.

<br>
7: Aguiar GC, Queiroz-Junior CM, Sitta GL, Amaral FA, Teixeira MM, Caliari MV,
Ferreira AJ. Mefenamic acid decreases inflammation but not joint lesions in
experimental osteoarthritis. Int J Exp Pathol. 2016 Dec;97(6):438-446. doi:
10.1111/iep.12216. PubMed PMID: 28370591; PubMed Central PMCID: PMC5370227.

<br>
8: Shiiba M, Yamagami H, Yamamoto A, Minakawa Y, Okamoto A, Kasamatsu A, Sakamoto
Y, Uzawa K, Takiguchi Y, Tanzawa H. Mefenamic acid enhances anticancer drug
sensitivity via inhibition of aldo-keto reductase 1C enzyme activity. Oncol Rep.
2017 Apr;37(4):2025-2032. doi: 10.3892/or.2017.5480. Epub 2017 Mar 1. PubMed
PMID: 28259989.

<br>
9: Savjani JK, Mulamkattil S, Variya B, Patel S. Molecular docking, synthesis and
biological screening of mefenamic acid derivatives as anti-inflammatory agents.
Eur J Pharmacol. 2017 Apr 15;801:28-34. doi: 10.1016/j.ejphar.2017.02.051. Epub
2017 Mar 1. PubMed PMID: 28259712.
<br>

10: Velázquez YF, Nacheva PM. Biodegradability of fluoxetine, mefenamic acid, and
metoprolol using different microbial consortiums. Environ Sci Pollut Res Int.
2017 Mar;24(7):6779-6793. doi: 10.1007/s11356-017-8413-y. Epub 2017 Jan 14.
PubMed PMID: 28091995.

Request a Quote