Mefloquine HCl

• CAT Number: A000127
• CAS Number: 51773-92-3
• Molecular Formula: C17H17ClF6N2O
• Molecular Weight: 414.77
• Purity: ≥95%
• Target: Autophagy
• Solubility: >20.7mg/mL in DMSO
• Storage: Store at -20°C
• IUPAC Name: (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol;hydrochloride
• InChI: InChI=1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
• InChIKey: WESWYMRNZNDGBX-YLCXCWDSSA-N
• SMILES: C1CCN[C@H](C1)[C@H](C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl

Mefloquine HCl（Cat No.:A000127）is a hydrochloride salt form of mefloquine, a quinoline-based antimalarial drug used to treat and prevent malaria caused by Plasmodium species, including drug-resistant strains. It acts by interfering with the parasite’s heme detoxification process, leading to toxic heme accumulation and parasite death. Known for its long half-life, Mefloquine HCl is effective with weekly dosing, making it convenient for travelers in malaria-endemic regions. Despite its efficacy, potential neuropsychiatric side effects warrant careful monitoring. Mefloquine HCl remains a key tool in combating malaria and managing resistant infections.