Mefox

For research use only. Not for therapeutic Use.

  • CAT Number: I031874
  • CAS Number: 79573-48-1
  • Molecular Formula: C20H23N7O7
  • Molecular Weight: 473.44
  • Purity: 98%
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Mefox (Cat.No:I031874) is an agricultural fungicide used to control fungal diseases in crops. It belongs to the group of benzimidazole fungicides and acts by inhibiting fungal cell division and growth. Mefox is effective against a wide range of plant pathogens, including powdery mildew, rusts, and leaf spot diseases. It is used in various agricultural settings to protect crops and improve yield.


Catalog Number I031874
CAS Number 79573-48-1
Synonyms

Mefox; (6RS)-Mefox;

Molecular Formula C20H23N7O7
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (4-(((2-amino-8-methyl-4,9-dioxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a][1,3,5]triazin-7-yl)methyl)amino)benzoyl)-L-glutamic acid
InChI InChI=1S/C20H23N7O7/c1-26-12(9-27-15(17(26)31)24-19(21)25-20(27)34)8-22-11-4-2-10(3-5-11)16(30)23-13(18(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,23,30)(H,28,29)(H,32,33)(H2,21,25,34)/t12?,13-/m0/s1
InChIKey AFIMZPFBSYESNQ-ABLWVSNPSA-N
SMILES O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C)C(C(N3C2)=NC(N)=NC3=O)=O)C=C1)=O
Reference

1: Ringling C, Rychlik M. Simulation of Food Folate Digestion and Bioavailability of an Oxidation Product of 5-Methyltetrahydrofolate. Nutrients. 2017 Sep 1;9(9). pii: E969. doi: 10.3390/nu9090969. PubMed PMID: 28862677; PubMed Central PMCID: PMC5622729.
2: Fazili Z, Sternberg MR, Paladugula N, Pfeiffer CM. Two International Round-Robin Studies Showed Good Comparability of 5-Methyltetrahydrofolate but Poor Comparability of Folic Acid Measured in Serum by Different High-Performance Liquid Chromatography-Tandem Mass Spectrometry Methods. J Nutr. 2017 Sep;147(9):1815-1825. doi: 10.3945/jn.117.254144. Epub 2017 Aug 2. PubMed PMID: 28768831; PubMed Central PMCID: PMC5712443.
3: Ringling C, Rychlik M. Origins of the difference between food folate analysis results obtained by LC-MS/MS and microbiological assays. Anal Bioanal Chem. 2017 Mar;409(7):1815-1825. doi: 10.1007/s00216-016-0126-4. Epub 2017 Jan 3. PubMed PMID: 28050625.
4: Pfeiffer CM, Sternberg MR, Fazili Z, Lacher DA, Zhang M, Johnson CL, Hamner HC, Bailey RL, Rader JI, Yamini S, Berry RJ, Yetley EA. Folate status and concentrations of serum folate forms in the US population: National Health and Nutrition Examination Survey 2011-2. Br J Nutr. 2015 Jun 28;113(12):1965-77. doi: 10.1017/S0007114515001142. Epub 2015 Apr 28. PubMed PMID: 25917925; PubMed Central PMCID: PMC4804191.
5: Fazili Z, Sternberg MR, Paladugula N, Whitehead RD Jr, Chen H, Pfeiffer CM. The loss of 5-methyltetrahydrofolate in human serum under suboptimal preanalytical conditions can only partially be recovered by an oxidation product. J Nutr. 2014 Nov;144(11):1873-9. doi: 10.3945/jn.114.198358. Epub 2014 Sep 17. PubMed PMID: 25332487; PubMed Central PMCID: PMC5332148.
6: Fazili Z, Whitehead RD Jr, Paladugula N, Pfeiffer CM. A high-throughput LC-MS/MS method suitable for population biomonitoring measures five serum folate vitamers and one oxidation product. Anal Bioanal Chem. 2013 May;405(13):4549-60. doi: 10.1007/s00216-013-6854-9. Epub 2013 Mar 6. PubMed PMID: 23462981; PubMed Central PMCID: PMC5326548.
7: Fazili Z, Pfeiffer CM. Accounting for an isobaric interference allows correct determination of folate vitamers in serum by isotope dilution-liquid chromatography-tandem MS. J Nutr. 2013 Jan;143(1):108-13. doi: 10.3945/jn.112.166769. Epub 2012 Nov 21. PubMed PMID: 23173171; PubMed Central PMCID: PMC5362735.

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