For research use only. Not for therapeutic Use.
Mefruside is a diuretic indicated for the treatment of edema and hypertension.
| Catalog Number | R042186 |
| CAS Number | 7195-27-9 |
| Synonyms | 4-Chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide; B 1500; BAY 1500; Baycaron; FBA 1500; FDA 1902; Mefrusid; N-(4-Chloro-3-sulfamoylbenzenesulfonyl)-N-methyl-2-furfurylamine; N-(4’-Chloro-3’-sulfamoylbenzenesulfon |
| Molecular Formula | C13H19ClN2O5S2 |
| Purity | ≥95% |
| Storage | Store at +4C |
| IUPAC Name | 4-chloro-1-N-methyl-1-N-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide |
| InChI | InChI=1S/C13H19ClN2O5S2/c1-13(6-3-7-21-13)9-16(2)23(19,20)10-4-5-11(14)12(8-10)22(15,17)18/h4-5,8H,3,6-7,9H2,1-2H3,(H2,15,17,18) |
| InChIKey | SMNOERSLNYGGOU-UHFFFAOYSA-N |
| SMILES | CC1(CCCO1)CN(C)S(=O)(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N |
| Reference | </br>1:Simultaneous determination of the binary mixture of nifedipine and mefruside using derivate spectroscopy, capillary gas-liquid chromatography and high performance liquid chromatography. el Walily AF.Acta Pharm Hung. 1997 Mar-May;67(2-3):89-97. PMID: 9223759 </br>2:Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters. Landmark K, Forsman M, Lindberg K, Ryman T, Martmann-Moe K, Haaverstad S, Wiel S.J Hum Hypertens. 1995 Apr;9(4):281-5. PMID: 7595911 </br>3:[Therapy of mild to moderate hypertension. Efficacy and tolerance of Amlodipine in comparison with the combination nifedipine/mefruside]. Höfling B, Häringer E, Herrmann W, Pieske H, Pieske R, Philippi M.Fortschr Med. 1991 May 20;109(15):327-30. German. PMID: 1830287 </br>4:Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension. Kirsten R, Heller A, Heintz B, Nelson K.J Hum Hypertens. 1990 Aug;4(4):461-4. PMID: 2258894 </br>5:Effect of nifedipine and mefruside on renal reserve in hypertensive patients. Notghi A, Anderton JL.Postgrad Med J. 1988 Nov;64(757):856-9. PMID: 3255934 Free PMC Article</br>6:Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension. Schulte KL, Meyer-Sabellek W, Röcker L, Gotzen R, Distler A.Am J Cardiol. 1987 Oct 1;60(10):826-31. PMID: 3661396 </br>7:[Mechanism of hypotensive action of a diuretic, mefruside, based on the pressure-natriuresis relationship]. Saito F, Kimura G, Shimozaki Y, Fujii T, Ishii T, Yoshida K, Abe H, Kawamura M, Deguchi F, Kawano Y, et al.Nihon Jinzo Gakkai Shi. 1987 Apr;29(4):461-7. Japanese. No abstract available. PMID: 3656703 </br>8:Effect of nifedipine and mefruside on renal function and platelet function in hypertensive patients. Notghi A, Fiskerstrand CE, Burnet ME, Anderton JL.Curr Med Res Opin. 1987;10(7):441-9. PMID: 3621989 </br>9:A double-blind, placebo-controlled, crossover trial to investigate the additive hypotensive effect of a diuretic (mefruside) to that produced by nifedipine. Poulter N, Thompson AV, Sever PS.J Cardiovasc Pharmacol. 1987;10 Suppl 10:S53-6. PMID: 2455140 </br>10:Thermal stability of mefruside-polyvinylpyrrolidone solid dispersions. Junginger HE, Wedler M.Pharm Res. 1986 Feb;3(1):41-4. doi: 10.1023/A:1016320831469. PMID: 24271355 |
