Meglutol-d3

• CAT Number: I041667
• CAS Number: 59060-36-5
• Molecular Formula: C6H7D3O5
• Molecular Weight: 165.16
• Purity: ≥95%
• Synonyms: 3-hydroxy-3-(trideuteriomethyl)pentanedioic acid
• InChI: InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)/i1D3
• InChIKey: NPOAOTPXWNWTSH-FIBGUPNXSA-N
• SMILES: CC(CC(=O)O)(CC(=O)O)O

Meglutol-d3 is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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