For research use only, not for therapeutic use.
Meisoindigo（Cat No.:I005710）, also known as Dian III, is a derivative of Indirubin (HY-N0117), which causes acute myeloid leukemia (AML) cell cycle arrest at G0/G1 phase and induces apoptosis. Meisoindigo has high antitumor activity.If you need, please contact us in time, we will reply you as soon as possible within 24 hours.
| Catalog Number | I005710 |
| CAS Number | 97207-47-1 |
| Synonyms | (3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one |
| Molecular Formula | C17H12N2O2 |
| Purity | ≥95% |
| Target | Apoptosis Inducers |
| Solubility | DMSO: ≥ 51 mg/mL |
| Storage | Sealed in dry,Room Temperature |
| IUPAC Name | 3-(2-hydroxy-1-methylindol-3-yl)indol-2-one |
| InChI | InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9,21H,1H3 |
| InChIKey | XZYXCQXTKOYHGK-UHFFFAOYSA-N |
| SMILES | CN1C2=CC=CC=C2C(=C1O)C3=C4C=CC=CC4=NC3=O |
| Reference | </br>1:Meisoindigo, but not its core chemical structure indirubin, inhibits zebrafish interstitial leukocyte chemotactic migration. Ye B, Xiong X, Deng X, Gu L, Wang Q, Zeng Z, Gao X, Gao Q, Wang Y.Pharm Biol. 2017 Dec;55(1):673-679. PMID: 27981893 </br>2:Evaluation of meisoindigo, an indirubin derivative: in vitro antileukemic activity and in vivo pharmacokinetics. Huang M, Lin HS, Lee YS, Ho PC.Int J Oncol. 2014 Oct;45(4):1724-34. doi: 10.3892/ijo.2014.2548. Epub 2014 Jul 21. PMID: 25050545 </br>3:[Mechanism about therapeutic effect of meisoindigo on psoriasis via down-regulation of the TLR4-TAK-NF-kappaB pathways]. Zhang HJ, Zhang Y, Jin J, Zhou WQ, Chen XG.Yao Xue Xue Bao. 2013 Apr;48(4):503-7. Chinese. PMID: 23833936 </br>4:[Immuno-regulatory effect of 3/’-meisoindigo in mice of various germlines]. Wang XJ, Yin SM, Ma LP, Nie DN, Xie SF, Li YQ.Zhong Yao Cai. 2010 Jul;33(7):1124-9. Chinese. PMID: 21137371 </br>5:[Effect of Meisoindigo on Wnt signal pathway in K562 and HL-60 cells]. Zuo MX, Li Y, Zhou JH, Wang HB, Chen XG.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Jun;18(3):579-82. Chinese. PMID: 20561405 </br>6:Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Lee CC, Lin CP, Lee YL, Wang GC, Cheng YC, Liu HE.Leuk Lymphoma. 2010 May;51(5):897-905. doi: 10.3109/10428191003672115. PMID: 20233051 </br>7:Identification of circulatory and excretory metabolites of meisoindigo in rat plasma, urine and feces by high-performance liquid chromatography coupled with positive electrospray ionization tandem mass spectrometry. Huang M, Lee YS, Ho PC.Rapid Commun Mass Spectrom. 2010 Mar;24(6):729-41. doi: 10.1002/rcm.4434. PMID: 20169560 </br>8:Identification of metabolites of meisoindigo in rat, pig and human liver microsomes by UFLC-MS/MS. Huang M, Ho PC.Biochem Pharmacol. 2009 Apr 15;77(8):1418-28. doi: 10.1016/j.bcp.2009.01.012. Epub 2009 Jan 29. PMID: 19426681 </br>9:[Effect on bcr-abl signaling pathway and the mechanisms of apoptosis induction by meisoindigo in K562 cells]. Liu BC, Xiao ZJ.Zhonghua Xue Ye Xue Za Zhi. 2008 Dec;29(12):815-8. Chinese. PMID: 19176035 </br>10:The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo. Mingxin Z, Yan L, Hongbo W, Jianhua Z, Hongyan L, He L, Hongqi X, Sen Z, Xiaoguang C.J Chemother. 2008 Dec;20(6):728-33. PMID: 19129071 |
