For research use only. Not for therapeutic Use.
MEK-IN-6 (Example 69) is a MEK inhibitor. MEK-IN-6 inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells (IC50: 2 nM). MEK-IN-6 can be used for research of cancer[1].
| Catalog Number | I041156 |
| CAS Number | 2845151-86-0 |
| Synonyms | 8-(2-fluoro-4-methylsulfanylanilino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6-dione |
| Molecular Formula | C18H20FN3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H20FN3O4S/c1-21-15(24)9-11-5-6-22(26-8-7-23)18(25)16(11)17(21)20-14-4-3-12(27-2)10-13(14)19/h3-4,9-10,20,23H,5-8H2,1-2H3 |
| InChIKey | TURWFFGYNJNSFK-UHFFFAOYSA-N |
| SMILES | CN1C(=O)C=C2CCN(C(=O)C2=C1NC3=C(C=C(C=C3)SC)F)OCCO |
| Reference | [1]. Shelley Allen, et al. 3,4-dihydro-2,7-naphthyridine-1,6(2h,7h)-diones as mek inhibitors. Patent. WO2022208391. |
