Melarsoprol(Mixture of Diastereomers)

• CAT Number: R042249
• CAS Number: 494-79-1
• Molecular Formula: C12H15AsN6OS2
• Molecular Weight: 398.335
• Purity: ≥95%
• Synonyms: Melarsen B; Melarsoprol; Melarsaprol B; RP 3854; 2-[4-[(4,6-Diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolane-4-methanol; p-[(4,6-Diamino-s-triazin-2-yl)amino]dithio-benzenearsonous Acid Cyclic (Hydroxymethyl)ethylene Ester
• Target: Parasite
• Storage: -20°C
• IUPAC Name: [2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol
• InChI: InChI=1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)
• InChIKey: JCYZMTMYPZHVBF-UHFFFAOYSA-N
• SMILES: C1C(S[As](S1)C2=CC=C(C=C2)NC3=NC(=NC(=N3)N)N)CO

Melarsoprol is an arsenical drug used in the treatment of African trypanosomiasis, or sleeping sickness, caused by Trypanosoma brucei. It exists as a mixture of diastereomers, with each isomer having distinct pharmacological properties. Despite its efficacy, melarsoprol treatment is associated with severe side effects, including neurotoxicity, which limits its use to late-stage infections when no other treatments are available.