For research use only. Not for therapeutic Use.
Melatonin（Cat No.:I004727）is a naturally occurring hormone produced by the pineal gland, primarily responsible for regulating the sleep-wake cycle, also known as the circadian rhythm. It is widely used as a supplement to manage sleep disorders such as insomnia, jet lag, and shift work-related sleep disturbances. Melatonin plays a role in various physiological processes, including immune function and antioxidant defense, making it a subject of interest in research on aging, neuroprotection, and cancer. Its safety profile and effectiveness make it a popular choice for improving sleep quality and circadian rhythm alignment.
| Catalog Number | I004727 |
| CAS Number | 73-31-4 |
| Synonyms | NSC 56423;NSC 113928;Regulin |
| Molecular Formula | C13H16N2O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO 47 mg/mLWater <1 mg/mLEthanol 47 mg/mL |
| Storage | -20°C |
| IUPAC Name | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide |
| InChI | InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) |
| InChIKey | DRLFMBDRBRZALE-UHFFFAOYSA-N |
| SMILES | CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC |
| Reference | </br>1:Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders. Pagan C, Goubran-Botros H, Delorme R, Benabou M, Lemière N, Murray K, Amsellem F, Callebert J, Chaste P, Jamain S, Fauchereau F, Huguet G, Maronde E, Leboyer M, Launay JM, Bourgeron T.Sci Rep. 2017 May 18;7(1):2096. doi: 10.1038/s41598-017-02152-x. PMID: 28522826 </br>2:Regulation of bone mass through pineal-derived melatonin-MT2 pathway. Sharan K, Lewis K, Furukawa T, Yadav VK.J Pineal Res. 2017 May 17. doi: 10.1111/jpi.12423. [Epub ahead of print] PMID: 28512916 </br>3:Melatonin influences the sonic hedgehog signaling pathway in porcine cumulus oocyte complexes. Lee S, Jin JX, Taweechaipaisankul A, Kim GA, Ahn C, Lee BC.J Pineal Res. 2017 May 17. doi: 10.1111/jpi.12424. [Epub ahead of print] PMID: 28512846 </br>4:[Melatonin in a woman/’s life: from birth to menopause]. Usoltseva EN, Bruhina EV, Danilova MV.Adv Gerontol. 2015;28(4):701-707. Russian. PMID: 28509458 </br>5:The melatonin immunomodulatory actions in radiotherapy. Najafi M, Shirazi A, Motevaseli E, Geraily G, Norouzi F, Heidari M, Rezapoor S.Biophys Rev. 2017 Apr;9(2):139-148. doi: 10.1007/s12551-017-0256-8. Epub 2017 Mar 27. Review. PMID: 28510090 Free PMC Article</br>6:Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. Jenwitheesuk A, Boontem P, Wongchitrat P, Tocharus J, Mukda S, Govitrapong P.EXCLI J. 2017 Mar 23;16:340-353. doi: 10.17179/excli2016-852. eCollection 2017. PMID: 28507478 Free PMC Article</br>7:Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization. Yi WJ, Kim TS.Int Immunopharmacol. 2017 May 12;48:146-158. doi: 10.1016/j.intimp.2017.05.006. [Epub ahead of print] PMID: 28505494 </br>8:Melatonin Secretion Is Increased in Children with Severe Traumatic Brain Injury. Marseglia L, D/’Angelo G, Manti S, Rulli I, Salvo V, Buonocore G, Reiter RJ, Gitto E.Int J Mol Sci. 2017 May 13;18(5). pii: E1053. doi: 10.3390/ijms18051053. PMID: 28505079 Free Article</br>9:The Effects of Melatonin in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial. Pakravan H, Ahmadian M, Fani A, Aghaee D, Brumanad S, Pakzad B.Adv Biomed Res. 2017 Apr 17;6:40. doi: 10.4103/2277-9175.204593. eCollection 2017. PMID: 28503495 Free PMC Article</br>10:Melatonin: Pharmacology, Functions and Therapeutic Benefits. Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N, Fougerou C.Curr Neuropharmacol. 2017 Apr;15(3):434-443. doi: 10.2174/1570159X14666161228122115. Review. PMID: 28503116 |
