For research use only. Not for therapeutic Use.
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.<br>Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with K<sub>m</sub> and V<sub>max</sub> of 36.8 μM and 0.08 nmol/min/mg protein, respectively.<br>Mildronate administered orally to rats for 10 days (150 mg/kg) elicits a reduction in myocardial free camitine and long-chain acyl carnitine content by 63.7 and 74.3%, respectively. Mildronate treatment (100 mg/kg, orally) subsequent administration of isoproterenol results in a reduction in free camitine concentration by 48.7% in comparison with the rats receiving isoproterenol. A prior administration of Mildronate effectively protects the myocardium from isoproterenol-induced variations in the content of ATP and myocardial energy charge, as well as preventing a rise in creatine phosphokinase and lactic dehydrogenase activity.
| Catalog Number | A000466 |
| CAS Number | 86426-17-7 |
| Synonyms | NA |
| Molecular Formula | C6H18N2O4 |
| Purity | ≥95% |
| Target | Mitochondrial Metabolism |
| Storage | 3 years -20C powder |
| Related CAS | 76144-81-5 |
| IUPAC Name | 3-[(trimethylazaniumyl)amino]propanoate;dihydrate |
| InChI | InChI=1S/C6H14N2O2.2H2O/c1-8(2,3)7-5-4-6(9)10;;/h7H,4-5H2,1-3H3;2*1H2 |
| InChIKey | JFWLFLLRLZSBRA-UHFFFAOYSA-N |
| SMILES | C[N+](C)(C)NCCC(=O)[O-].O.O |
