For research use only. Not for therapeutic Use.
Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor[1][2].
Meldonium (20-40 μM; 24 h) ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3].
Meldonium (50, 100, or 200 mg/kg; once daily for 3 days) modestly attenuates hypoxia-induced lung injury in mice[3].
| Catalog Number | R007504 |
| CAS Number | 76144-81-5 |
| Synonyms | 3-[(trimethylazaniumyl)amino]propanoate |
| Molecular Formula | C6H14N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3 |
| InChIKey | PVBQYTCFVWZSJK-UHFFFAOYSA-N |
| SMILES | C[N+](C)(C)NCCC(=O)[O-] |
| Reference | [1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [2]. Jolanta Pupure, et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett. 2010 Feb 12;470(2):100-5. [3]. Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451. |
