For research use only. Not for therapeutic Use.
Melflufen Hydrochloride（Cat No.:I014770）is a peptide-conjugated alkylating agent designed to deliver cytotoxic effects specifically to cancer cells. It is a prodrug of melphalan, activated by aminopeptidases that are highly expressed in tumor cells. Once activated, it releases alkylating agents that cause DNA damage, leading to cell death. Melflufen Hydrochloride has shown significant efficacy in the treatment of multiple myeloma and is being studied for its potential in other cancers. Its targeted delivery mechanism reduces systemic toxicity, making it a promising therapeutic option in cancer research and treatment.
| Catalog Number | I014770 |
| CAS Number | 380449-54-7 |
| Synonyms | Melflufen hydrochloride; Melphalan flufenamide hydrochloride |
| Molecular Formula | C₂₄H₃₁Cl₃FN₃O₃ |
| Purity | 98% |
| Target | Apoptosis |
| Appearance | Off-white to light yellow (Solid) |
| Related CAS | 380449-51-4 |
| Analysis method | HPLC |
| IUPAC Name | ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate;hydrochloride |
| InChI | InChI=1S/C24H30Cl2FN3O3.ClH/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26;/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31);1H/t21-,22-;/m0./s1 |
| InChIKey | ZCMWSKHHXLCVHI-VROPFNGYSA-N |
| SMILES | CCOC(=O)[C@H](CC1=CC=C(C=C1)F)NC(=O)[C@H](CC2=CC=C(C=C2)N(CCCl)CCCl)N.Cl |
| Reference | [1]. Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19(11):3019-3031. <br>[2]. Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174(3):397-409. <br>[3]. McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52. |
