Meprednisone

• CAT Number: A000198
• CAS Number: 1247-42-3
• Molecular Formula: C22H28O5
• Molecular Weight: 372.45
• Purity: ≥95%
• Synonyms: NSC 527579, SCH 4358
• Target: Glucocorticoid Receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/m0/s1
• InChIKey: PIDANAQULIKBQS-RNUIGHNZSA-N
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3C(=O)CC2(C1(C(=O)CO)O)C)C

Meprednisone, also known as NSC-63278 and Betapar, is a glucocorticoid receptor agonist used to treat allergic and inflammatory of the eye.

Reference

1: Ma X, He J, Yan J, Wang Q, Li H. Comparative analysis the binding affinity of
mycophenolic sodium and meprednisone with human serum albumin: Insight by NMR
relaxation data and docking simulation. Chem Biol Interact. 2016 Mar 25;248:52-9.
doi: 10.1016/j.cbi.2016.02.009. Epub 2016 Feb 16. PubMed PMID: 26892221.

2: Fernández D, Vega D, Ellena JA.
17alpha,21-Dihydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione (meprednisone).
Acta Crystallogr C. 2003 Apr;59(Pt 4):O187-9. Epub 2003 Mar 11. PubMed PMID:
12682403.

3: Meprednisone (betapar). Med Lett Drugs Ther. 1971 Dec 24;13(26):106-7. PubMed
PMID: 5163919.