For research use only. Not for therapeutic Use.
Meptazinol, also known as IL 22811 and WY 22811, is an opioid analgesic developed by Wyeth in the 1970s. Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth). Meptazinol is a 3-phenylazpane derivative, whereas the other phenazepanes like ethoheptazine and proheptazine are 4-phenylazepanes. A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine
| Catalog Number | I007957 |
| CAS Number | 59263-76-2 (HCl) |
| Synonyms | Meptazinol Hydrochloride, IL 22811 HCl; IL-22811; IL22811; WY 22811; WY-22811; WY22811. trade name Meptid.;3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol hydrochloride |
| Molecular Formula | C15H24ClNO |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 3-(3-ethyl-1-methylazepan-3-yl)phenol;hydrochloride |
| InChI | InChI=1S/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H |
| InChIKey | MPJUSISYVXABBH-UHFFFAOYSA-N |
| SMILES | CCC1(CCCCN(C1)C)C2=CC(=CC=C2)O.Cl |
| Reference | </br>1: Singer J, Jank A, Amara S, Stepan PD, Kaisers U, Hoehne C. Efficacy and Effects of Parenteral Pethidine or Meptazinol and Regional Analgesia for Pain Relief during Delivery. A Comparative Observational Study. Geburtshilfe Frauenheilkd. 2016 Sep;76(9):964-971. PubMed PMID: 27681521; PubMed Central PMCID: PMC5033648.</br>2: Bajda M, Panek D, Hebda M, Więckowska A, Guzior N, Malawska B. SEARCH FOR POTENTIAL CHOLINESTERASE INHIBITORS FROM THE ZINC DATABASE BY VIRTUAL SCREENING METHOD. Acta Pol Pharm. 2015 Jul-Aug;72(4):737-45. PubMed PMID: 26647631. |
