Meropenem trihydrate

• CAT Number: I000709
• CAS Number: 119478-56-7
• Molecular Formula: C17H31N3O8S
• Molecular Weight: 437.51
• Purity: ≥95%
• Synonyms: (4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate
• Target: Antibiotic
• Solubility: DMSO 77 mg/mL; Water 8 mg/mL; Ethanol <1 mg/mL
• Storage: Store at -20C
• InChI: InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1
• InChIKey: CTUAQTBUVLKNDJ-OBZXMJSBSA-N
• SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O.O.O.O

Meropenem Trihydrate（Cat No.:I000709）is a broad-spectrum, carbapenem antibiotic used to treat severe bacterial infections, particularly in hospital settings. Effective against a wide range of Gram-positive and Gram-negative bacteria, including multi-drug resistant strains, it works by inhibiting bacterial cell wall synthesis, leading to rapid cell death. The trihydrate form improves its stability and solubility for intravenous administration, ensuring efficient delivery in critical cases like septicemia, meningitis, and intra-abdominal infections. Meropenem Trihydrate is valued for its resistance to β-lactamases, making it a vital option in combating antibiotic-resistant infections.

Reference

[1]. Slaney, L., et al., In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother, 1989. 24 Suppl A: p. 183-6.
[2]. Yang, Y.J. and D.M. Livermore, Interactions of meropenem with class I chromosomal beta-lactamases. J Antimicrob Chemother, 1989. 24 Suppl A: p. 207-17.
[3]. Makino, J., et al., [Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy]. Jpn J Antibiot, 2002. 55(1): p. 77-88.