Mesotrione

• CAT Number: R041798
• CAS Number: 104206-82-8
• Molecular Formula: C14H13NO7S
• Molecular Weight: 339.32
• Purity: ≥95%
• Synonyms: 2-(4-methylsulfonyl-2-nitrobenzoyl)cyclohexane-1,3-dione
• InChI: InChI=1S/C14H13NO7S/c1-23(21,22)8-5-6-9(10(7-8)15(19)20)14(18)13-11(16)3-2-4-12(13)17/h5-7,13H,2-4H2,1H3
• InChIKey: KPUREKXXPHOJQT-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)C2C(=O)CCCC2=O)[N+](=O)[O-]

Mesotrione is a herbicide belongs to the benzoylcyclohexanedione family. Mesotrione is a potent and competitive and reversible inhibitor of HPPD enzyme. Mesotrione is selective to maize due to rapid metabolism and relative high tolerance by the susceptible crop plant[1].
Mesotrione is a potent HPPD enzyme inhibitor, giving an estimated Ki value in the range 6±18pM at 25°C. HPPD is from Arabidopsis thaliana (L)[1].
Mesotrione (oral administration; 1 mg/kg; single dose) is rapidly and extensively absorbed in rats and mice. After a single dose, the urinary excretione is estimated, the urinary excretione estimated absorption values ranged from 62.2% in males and 68.3% in females. The mean peak blood concentration (Cmax) of radioactivity occurred 0.5 hours after dosing in each sex[1].

Reference

[1]. G Mitchell, et al. Mesotrione: A New Selective Herbicide for Use in Maize.Pest Manag Sci.2001 Feb;57(2):120-8.
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[2]. CLH report.Proposal for Harmonised Classification and Labelling.Based on Regulation (EC) No 1272/2008 (CLP Regulation), Annex VI, Part 2.Substance Name: Mesotrione