For research use only. Not for therapeutic Use.
Mestranol (Cat.No:I004692) is a synthetic estrogen derivative and a prodrug of ethinylestradiol. It is used as an oral contraceptive in combination with a progestin. Mestranol is converted to ethinylestradiol in the body, which helps to prevent pregnancy by inhibiting ovulation and altering the cervical mucus and uterine lining.
| Catalog Number | I004692 |
| CAS Number | 72-33-3 |
| Molecular Formula | C21H26O2 |
| Purity | ≥95% |
| Target | Estrogen Receptor/ERR |
| Solubility | DMSO 15 mg/mL; Water <1 mg/mL; Ethanol 25 mg/mL |
| Storage | 3 years -20C powder |
| Reference | </br>1:Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. Perreault M, Maltais R, Roy J, Dutour R, Poirier D.ChemMedChem. 2017 Jan 20;12(2):177-182. doi: 10.1002/cmdc.201600482. Epub 2017 Jan 6. PMID: 28060448 </br>2:Effect of CYP2C9 Genetic Polymorphism in a Chinese Population on the Metabolism of Mestranol in vitro. Hu JH, Wang L, Li WS, Dai DP, Cai JP, Hu GX.Pharmacology. 2015;95(5-6):218-23. doi: 10.1159/000381189. Epub 2015 Apr 25. PMID: 25924705 </br>3:Improved synthesis of mestranol and ethinyl estradiol (EE) related degradation products as authentic references. Li H, Song Y, Peng X.Steroids. 2008 May;73(5):488-94. doi: 10.1016/j.steroids.2007.12.024. Epub 2007 Dec 28. PMID: 18255111 </br>4:Viscosity studies on Mestranol. Akhtar S, Ahmad T, Hassan F, Arif M, Hassan S.Pak J Pharm Sci. 1998 Jul;11(2):1-4. PMID: 16414812 </br>5:Microbial transformation of mestranol by Cunninghamella elegans. Choudhary MI, Musharraf SG, Siddiqui ZA, Khan NT, Ali RA, Ur-Rahman A.Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1011-3. PMID: 16079537 Free Article</br>6:Effect of chronic administration of mestranol, tamoxifen, and toremifene on hepatic ploidy in rats. Dragan YP, Shimel RJ, Bahnub N, Sattler G, Vaughan JR, Jordan VC, Pitot HC.Toxicol Sci. 1998 Jun;43(2):129-38. PMID: 9710954 </br>7:Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. Schmider J, Greenblatt DJ, von Moltke LL, Karsov D, Vena R, Friedman HL, Shader RI.J Clin Pharmacol. 1997 Mar;37(3):193-200. PMID: 9089421 </br>8:Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat. Dragan YP, Singh J, Pitot HC.Carcinogenesis. 1996 Sep;17(9):2043-52. PMID: 8824533 </br>9:[Effect of mestranol on pharmacokinetics of phenazone in the rabbit]. Gawrońska-Szklarz B, Droździk M, Kwiatkowski A, Wójcicki J.Ginekol Pol. 1996 Jan;67(1):1-6. Polish. PMID: 8655012 </br>10:[Estrogens. Replacement therapy. Mestranol 80 ug (1962) versus mestranol 20 ug (1994) in postmenopausal women. Clinical, local, and metabolic effects]. Cortés Gallegos V, Sojo Aranda I.Ginecol Obstet Mex. 1995 Jan;63:55-8. Spanish. PMID: 7896161 |
