For research use only. Not for therapeutic Use.
Metaproterenol (Cat No.:R053578), also known as Th-152, is used to treat asthmatic children with high serum theophylline concentration. Epinephrine hemisulfate (Epinephrine hemisulfate) is a direct-acting sympathomimetic drug β 2-adrenergic receptor（ β 2AR) agonist whose IC50 is 68 nM. Isoproterenol hemisulfate also has anti-inflammatory activity.
| Catalog Number | R053578 |
| CAS Number | 5874-97-5 |
| Synonyms | 5-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol Sulfate; 3,5-Dihydroxy-α-[(isopropylamino)methyl]benzyl Alcohol Sulfate; (±)-Orciprenaline Sulfate; 1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane Sulfate; 3,5-Dihydroxy-α-[(isopro |
| Molecular Formula | C22H36N2O10S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | 5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol;sulfuric acid |
| InChI | InChI=1S/2C11H17NO3.H2O4S/c2*1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8;1-5(2,3)4/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4) |
| InChIKey | MKFFGUZYVNDHIH-UHFFFAOYSA-N |
| SMILES | CC(C)NCC(C1=CC(=CC(=C1)O)O)O.CC(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O |
| Reference | </br>1: Schilero GJ, Grimm D, Spungen AM, Lenner R, Lesser M. Bronchodilator responses to metaproterenol sulfate among subjects with spinal cord injury. J Rehabil Res Dev. 2004 Jan-Feb;41(1):59-64. PubMed PMID: 15273898. </br> 2: Elyan BM, Sidhom MB, Plakogiannis FM. Evaluation of the effect of different fatty acids on the percutaneous absorption of metaproterenol sulfate. J Pharm Sci. 1996 Jan;85(1):101-5. PubMed PMID: 8926573. </br> 3: Karpel JP, Pesin J, Greenberg D, Gentry E. A comparison of the effects of ipratropium bromide and metaproterenol sulfate in acute exacerbations of COPD. Chest. 1990 Oct;98(4):835-9. PubMed PMID: 2145136. </br> 4: Nussbaum E, Eyzaguirre M, Galant SP. Dose-response relationship of inhaled metaproterenol sulfate in preschool children with mild asthma. Pediatrics. 1990 Jun;85(6):1072-5. PubMed PMID: 2187175. </br> 5: McCalden TA, Porter J, Kamarei A. Aerosol delivery of liposome metaproterenol sulfate. Proc West Pharmacol Soc. 1990;33:171-3. PubMed PMID: 2274531. </br> 6: Appel D, Karpel JP, Sherman M. Epinephrine improves expiratory flow rates in patients with asthma who do not respond to inhaled metaproterenol sulfate. J Allergy Clin Immunol. 1989 Jul;84(1):90-8. PubMed PMID: 2754149. </br> 7: Linn WS, Avol EL, Shamoo DA, Peng RC, Spier CE, Smith MN, Hackney JD. Effect of metaproterenol sulfate on mild asthmatics/’ response to sulfur dioxide exposure and exercise. Arch Environ Health. 1988 Nov-Dec;43(6):399-406. PubMed PMID: 3196076. </br> 8: Menon P, Hilman BC, Menon V, Bairnsfather L. Assessment of response to oral metaproterenol sulfate by forced oscillation in young children. Ann Allergy. 1988 Jun;60(6):547-51. PubMed PMID: 3382060. </br> 9: Rogers JC. Combined inhalation of cromolyn sodium and metaproterenol sulfate in life-threatening asthma. J Fam Pract. 1988 Feb;26(2):193-5. PubMed PMID: 3123591. </br> 10: McCalden TA, Abra RA, Mihalko PJ. Bronchodilator effects of some liposome formulations of metaproterenol sulfate in guinea pigs. Proc West Pharmacol Soc. 1988;31:129-32. PubMed PMID: 3211892. </br> 11: Nussbaum E, Galant SP. Bronchodilator effects of oral metaproterenol sulfate in preschool children with asthma. J Pediatr. 1987 Jan;110(1):148-51. PubMed PMID: 3794877. </br> 12: Karpel JP, Appel D, Breidbart D, Fusco MJ. A comparison of atropine sulfate and metaproterenol sulfate in the emergency treatment of asthma. Am Rev Respir Dis. 1986 May;133(5):727-9. PubMed PMID: 3706879. </br> 13: Berkowitz R, Schwartz E, Bukstein D, Grunstein M, Chai H. Albuterol protects against exercise-induced asthma longer than metaproterenol sulfate. Pediatrics. 1986 Feb;77(2):173-8. PubMed PMID: 3945530. </br> 14: Salzman GA, Pyszczynski DR. A comparison of two delivery methods for aerosolized metaproterenol sulfate. J Asthma. 1986;23(6):297-301. PubMed PMID: 3818510. </br> 15: Appel DW. Effect of aminophylline when added to metaproterenol sulfate and beclomethasone dipropionate aerosol. J Allergy Clin Immunol. 1984 Feb;73(2):291-7. PubMed PMID: 6699312. </br> 16: Berquist WE, Rachelefsky GS, Rowshan N, Siegel S, Katz R, Welch M. Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy. J Allergy Clin Immunol. 1984 Feb;73(2):253-8. PubMed PMID: 6699308. </br> 17: Sane RT, Sawant SV, Doshi VJ, Mhalas JG, Paarikh AK, Gijare AS, Deshpande DS. Simple colorimetric method for determination of metaproterenol sulfate in pharmaceuticals. J Assoc Off Anal Chem. 1984 Jan-Feb;67(1):137-8. PubMed PMID: 6698920. </br> 18: Peerless AG, Rachelefsky GS, Mickey MR, Katz RM, Siegel SC. Bronchodilator characteristics of nebulized metaproterenol sulfate, isoetharine, and atropine in chronic asthma. J Allergy Clin Immunol. 1983 Dec;72(6):702-8. PubMed PMID: 6358329. </br> 19: Kelly HW, Menendez R, Murphy S, Tuttle W. Metaproterenol sulfate for asthmatic children with therapeutic serum theophylline concentrations. Clin Pharm. 1982 Jan-Feb;1(1):49-54. PubMed PMID: 6764162. </br> 20: Geumei AM, Miller WF, Miller J, Gast LR. Bronchodilator effect of a new oral beta adrenoreceptor stimulant, Th1165a. A comparison with metaproterenol sulfate. Chest. 1976 Oct;70(4):460-5. PubMed PMID: 789024. </br></br> |
