For research use only. Not for therapeutic Use.
Metarrestin（Cat No.:I018156）is a small molecule inhibitor that targets the protein Arrestin-3, which is involved in regulating cellular signaling pathways, including those associated with G-protein coupled receptors (GPCRs). By inhibiting Arrestin-3, Metarrestin disrupts abnormal cell signaling, which can contribute to tumor growth and metastasis, particularly in cancers like breast cancer. Research has shown that Metarrestin may help in reducing cancer cell migration, invasion, and metastasis. Its potential therapeutic applications are being explored, especially in cancers where Arrestin-3-related signaling plays a key role in disease progression.
| Catalog Number | I018156 |
| CAS Number | 1443414-10-5 |
| Molecular Formula | C₃₁H₃₀N₄O |
| Purity | ≥95% |
| Target | DNA/RNA Synthesis |
| IUPAC Name | 4-(7-benzyl-4-imino-5,6-diphenylpyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol |
| InChI | InChI=1S/C31H30N4O/c32-30-28-27(23-12-6-2-7-13-23)29(24-14-8-3-9-15-24)34(20-22-10-4-1-5-11-22)31(28)33-21-35(30)25-16-18-26(36)19-17-25/h1-15,21,25-26,32,36H,16-20H2 |
| InChIKey | WSMXAUJFLWRPNT-UHFFFAOYSA-N |
| SMILES | C1CC(CCC1N2C=NC3=C(C2=N)C(=C(N3CC4=CC=CC=C4)C5=CC=CC=C5)C6=CC=CC=C6)O |
| Reference | [1]. Vilimas T, et al. Pharmacokinetic evaluation of the perinucleolar compartment disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080.<br>[2]. Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441). |
