Metformin-d6, Hydrochloride

• CAT Number: R006493
• CAS Number: 1185166-01-1
• Molecular Formula: C4H12ClN5
• Molecular Weight: 171.662
• Purity: ≥95%
• Synonyms: N,N-Dimethylimidodicarbonimidic Diamide-d6, Hydrochloride; Diabetosan-d6; Diabex-d6, Glucophage-d6; Metiguanide-d6
• Target: PI3K/Akt/mTOR
• Storage: -20°C
• IUPAC Name: 3-(diaminomethylidene)-1,1-bis(trideuteriomethyl)guanidine;hydrochloride
• InChI: InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H/i1D3,2D3
• InChIKey: OETHQSJEHLVLGH-TXHXQZCNSA-N
• SMILES: [2H]C([2H])([2H])N(C(=N)N=C(N)N)C([2H])([2H])[2H].Cl

Metformin-d6 Hydrochloride is a deuterium-labeled version of metformin hydrochloride, a widely used antidiabetic medication that improves insulin sensitivity and reduces glucose production in the liver. The deuterium labeling enhances the compound’s use in pharmacokinetic and metabolic studies, enabling precise tracking of metformin and its metabolites using mass spectrometry. This is crucial for understanding its absorption, distribution, metabolism, and excretion in clinical research. Additionally, the labeled form serves as an internal standard in analytical chemistry for validating and calibrating methods, ensuring accurate measurement of metformin in pharmaceutical formulations and biological samples.