Methisosildenafil-d4

• CAT Number: R046221
• CAS Number: 1246819-66-8
• Molecular Formula: C23H32N6O4S
• Molecular Weight: 492.631
• Purity: ≥95%
• Synonyms: rel-5-[5-[[(3R,5S)-3,5-Dimethyl-1-piperazinyl-d4]sulfonyl]-2-ethoxyphenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one; Aildenafil-d4
• Storage: 3 years -20C powder
• IUPAC Name: 5-[2-ethoxy-5-[(3S,5R)-2,2,6,6-tetradeuterio-3,5-dimethylpiperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
• InChI: InChI=1S/C23H32N6O4S/c1-6-8-18-20-21(28(5)27-18)23(30)26-22(25-20)17-11-16(9-10-19(17)33-7-2)34(31,32)29-12-14(3)24-15(4)13-29/h9-11,14-15,24H,6-8,12-13H2,1-5H3,(H,25,26,30)/t14-,15+/i12D2,13D2
• InChIKey: NFSWSZIPXJAYLR-DXCCVUCUSA-N
• SMILES: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CC(NC(C4)C)C)OCC)C

Methisosildenafil-d4 is a deuterated analog of the phosphodiesterase type 5 (PDE5) inhibitor sildenafil, used in advanced pharmaceutical and biochemical research. This compound, labeled with four deuterium atoms, is essential for studying drug metabolism, pharmacokinetics, and the mechanism of action of PDE5 inhibitors. Its stable isotope labeling ensures precise and reliable data, reducing background interference in analytical applications such as mass spectrometry and NMR spectroscopy. Methisosildenafil-d4 provides researchers with enhanced accuracy in tracing and quantifying the drug’s behavior in biological systems, supporting the development of more effective treatments for erectile dysfunction and pulmonary arterial hypertension.