Methotrexate-d3

• CAT Number: R004387
• CAS Number: 432545-63-6
• Molecular Formula: C20H22N8O5
• Molecular Weight: 457.465
• Purity: ≥95%
• Synonyms: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino-d3]benzoyl]-L-glutamic Acid; (+)-Amethopterin; 4-Amino-N10-methylpteroylglutamic Acid-d3; 4-Amino-N10-methylfolic Acid-d3; Antifolan-d3; Emtexate-d3; Ledertrexate-d3; MTX-d3; L-Metatrexan-d3; Methyl
• Target: Antibody-drug Conjugate/ADC Related
• Storage: 2°C to 8°C
• IUPAC Name: 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-(trideuteriomethyl)amino]benzoyl]amino]pentanedioic acid
• InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/i1D3
• InChIKey: FBOZXECLQNJBKD-FIBGUPNXSA-N
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Methotrexate-d3 is a deuterated form of methotrexate, featuring three deuterium atoms. This high-purity compound is essential for advanced pharmaceutical and biochemical research, particularly in studying the pharmacokinetics, metabolic pathways, and drug interactions of methotrexate. Its stable isotope labeling ensures precise and reliable analytical results. Methotrexate-d3 is ideal for research on antifolate chemotherapy and autoimmune disease treatments, providing a robust and consistent tool for high-precision scientific investigations, seamlessly integrating into existing research protocols.