Methotrexate Dimethylamide

• CAT Number: R029977
• CAS Number: 71074-44-7
• Molecular Formula: C₂₂H₂₇N₉O₄
• Molecular Weight: 481.51
• Purity: ≥95%
• Synonyms: N2-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-L-glutamine; NSC 281286
• Storage: -20°C
• IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(dimethylamino)-5-oxopentanoic acid
• InChI: InChI=1S/C22H27N9O4/c1-30(2)16(32)9-8-15(21(34)35)27-20(33)12-4-6-14(7-5-12)31(3)11-13-10-25-19-17(26-13)18(23)28-22(24)29-19/h4-7,10,15H,8-9,11H2,1-3H3,(H,27,33)(H,34,35)(H4,23,24,25,28,29)/t15-/m0/s1
• InChIKey: BHFZGVOUGIGQGR-HNNXBMFYSA-N
• SMILES: CN(C)C(=O)CCC(C(=O)O)NC(=O)C1=CC=C(C=C1)N(C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N

Methotrexate dimethylamide（Cat No.:R029977）, is a chemical compound derived from methotrexate, a medication used in the treatment of cancer, autoimmune diseases, and certain skin conditions. Methotrexate dimethylamide is a derivative that may have been synthesized for research purposes or to explore potential modifications of methotrexate for improved therapeutic properties. Methotrexate itself works by inhibiting the growth and replication of rapidly dividing cells, including cancer cells and those involved in autoimmune diseases. It is considered a disease-modifying antirheumatic drug (DMARD) in the treatment of rheumatoid arthritis and has shown efficacy in the management of various medical conditions.