Methotrexate disodium salt

• CAT Number: M004548
• CAS Number: 7413-34-5
• Molecular Formula: C20H20N8Na2O5
• Molecular Weight: 498.41
• Purity: ≥95%
• Synonyms: 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt;amethopterinsodium;disodiummethotrexate;l-(+)-isodiumsal;mtxdisodium;METHOTREXATE DISODIUM;METHOTREXATE DISODIUM SALT;Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-gluta
• Storage: -20°C
• IUPAC Name: disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
• InChI: InChI=1S/C20H22N8O5.2Na/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);;/q;2*+1/p-2/t13-;;/m0../s1
• InChIKey: DASQOOZCTWOQPA-GXKRWWSZSA-L
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Methotrexate disodium salt（Cat No.:M004548）is a widely used chemotherapeutic and immunosuppressive agent that inhibits dihydrofolate reductase (DHFR), an enzyme critical for DNA synthesis and cell proliferation. By blocking DHFR, Methotrexate disrupts folate metabolism, leading to reduced nucleotide production and impaired DNA replication, particularly in rapidly dividing cancer cells. It is used to treat various cancers, including leukemia, breast cancer, and lymphoma, as well as autoimmune diseases such as rheumatoid arthritis. The disodium salt form enhances its solubility, making it suitable for both oral and injectable formulations in clinical use.