For research use only. Not for therapeutic Use.
Methoxsalen is a naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen/’s exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
| Catalog Number | A001183 |
| CAS Number | 298-81-7 |
| Synonyms | Xanthotoxin, NCI-C55903 |
| Molecular Formula | C12H8O4 |
| Purity | ≥95% |
| Target | Cytochrome P450 |
| Storage | 3 years -20C powder |
| Reference | </br>1:The adverse effects of the methoxsalen and ultraviolent A radiation on spermatogenesis in mice. Farhadi M, Mohseni Kouchesfahani H, Shockravi A, Foroozanfar M, Parivar K.Iran J Reprod Med. 2015 Aug;13(8):489-94. PMID: 26568751 Free PMC Article</br>2:Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment. Garg BJ, Garg NK, Beg S, Singh B, Katare OP.J Drug Target. 2016;24(3):233-46. doi: 10.3109/1061186X.2015.1070855. Epub 2015 Aug 12. PMID: 26325228 </br>3:Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment. Garg BJ, Garg NK, Beg S, Singh B, Katare OP.J Drug Target. 2016 Mar;24(3):233-246. Epub 2015 Aug 12. PMID: 26267289 </br>4:Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. Bagdas D, Muldoon PP, Zhu AZ, Tyndale RF, Damaj MI.Neuropharmacology. 2014 Oct;85:67-72. doi: 10.1016/j.neuropharm.2014.05.006. Epub 2014 May 21. PMID: 24859605 Free PMC Article</br>5:The adverse effects of methoxsalen on the oogenesis of BALB/c mice. Farhadi M, Fattahi E, Mohseni Kouchesfahani H, Shockravi A, Parivar K.Cell J. 2014 Winter;15(4):348-55. Epub 2013 Nov 20. PMID: 24381860 Free PMC Article</br>6:Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor. Alsharari SD, Siu EC, Tyndale RF, Damaj MI.Nicotine Tob Res. 2014 Jan;16(1):18-25. doi: 10.1093/ntr/ntt105. Epub 2013 Jul 24. PMID: 23884323 Free PMC Article</br>7:Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment. Kim JK, Choi SJ, Bae H, Kim CR, Cho HY, Kim YJ, Lim ST, Kim CJ, Kim HK, Peterson S, Shin DH.Biosci Biotechnol Biochem. 2011;75(10):1984-9. Epub 2011 Oct 7. PMID: 21979070 Free Article</br>8:Methoxsalen with ultraviolet A therapy. National Toxicology Program..Rep Carcinog. 2011;12:259-61. No abstract available. PMID: 21860476 Free Article</br>9:Extracorporeal methoxsalen: new drug. Cutaneous T cell lymphoma: for rare patients, but better assessment needed. [No authors listed]Prescrire Int. 2009 Feb;18(99):16. No abstract available. PMID: 19388212 </br>10:Automated liquid-liquid extraction based on 96-well plate format in conjunction with ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) for the quantitation of methoxsalen in human plasma. Yadav M, Contractor P, Upadhyay V, Gupta A, Guttikar S, Singhal P, Goswami S, Shrivastav PS.J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):167-71. doi: 10.1016/j.jchromb.2008.06.058. Epub 2008 Jul 15. PMID: 18656428 |
