Methoxy-PEPy

• CAT Number: I003920
• CAS Number: 524924-76-3
• Molecular Formula: C13H10N2O
• Molecular Weight: 210.24
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 1 nM
• IUPAC Name: 3-methoxy-5-(2-pyridin-2-ylethynyl)pyridine
• InChI: InChI=1S/C13H10N2O/c1-16-13-8-11(9-14-10-13)5-6-12-4-2-3-7-15-12/h2-4,7-10H,1H3
• InChIKey: VRTFKUFTEWQHDD-UHFFFAOYSA-N
• SMILES: COC1=CN=CC(=C1)C#CC2=CC=CC=N2

Methoxy-PEPy(CAT: I003920) is a potent and highly selective metabotropic glutamate receptor 5 (mGlu5) antagonist. By inhibiting mGlu5 receptor activity, it modulates glutamatergic neurotransmission, which is critical in various neurological processes. This mechanism makes Methoxy-PEPy valuable in neurological and psychiatric research, particularly for studying disorders like anxiety, depression, schizophrenia, and neurodegenerative diseases. Its high selectivity ensures targeted modulation of mGlu5 without affecting other glutamate receptors, offering precise insights into mGlu5-related signaling pathways. Methoxy-PEPy is an essential tool for developing potential therapies targeting glutamate-mediated neurological dysfunctions.