Methoxylamine Hydrochloride

• CAT Number: R057798
• CAS Number: 593-56-6
• Molecular Formula: CH6ClNO
• Molecular Weight: 83.515
• Purity: ≥95%
• Synonyms: O-Methylhydroxylamine Hydrochloride; (Aminooxy)methane Hydrochloride; Hydroxylamine Methyl Ether Hydrochloride; Methoxyamine Hydrochloride; Methoxyammonium Chloride; N-Methoxylamine Hydrochloride; O-Methoxyamine Hydrochloride; O-Methylhydroxylamine H
• Target: Apoptosis
• Storage: Store at -20°C
• IUPAC Name: O-methylhydroxylamine;hydrochloride
• InChI: InChI=1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H
• InChIKey: XNXVOSBNFZWHBV-UHFFFAOYSA-N
• SMILES: CON.Cl

Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Reference

1:Int J Biochem. 1980;11(6):565-7. Inhibition of human thrombin by methoxylamine hydrochloride.Longas MO,Finlay TH, PMID: 7380081