Methyl [[1-[4-[[(4-Fluorobenzyl)amino]carbonyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-1-methylethyl]amino](oxo)acetate

• CAT Number: C000271
• CAS Number: 518048-04-9
• Molecular Formula: C₁₉H₂₁FN₄O₆
• Molecular Weight: 420.39
• Purity: ≥95%
• Synonyms: Methyl [[1-[4-[[[(4-Fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]amino]oxo-acetic Acid
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White Solid
• Storage: -20°C

Methyl [[1-[4-[[(4-Fluorobenzyl)amino]carbonyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-1-methylethyl]amino](oxo)acetate(CAT: C000271) emerges as a significant intermediate in the synthesis of 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) 2-(2-Amino-2-oxoacetic Acid) Raltegravir, a derivative of Raltegravir. Raltegravir stands as a potent inhibitor of human immunodeficiency virus (HIV) integrase, a key enzyme in the viral replication process. The compound’s synthesis underscores its importance in drug development, offering insights into the strategic design and synthesis of derivatives that target critical components of the virus.

Reference

Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006)