For research use only. Not for therapeutic Use.
Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016097 |
| CAS Number | 1807521-04-5 |
| Synonyms | tert-butyl 3-[2-[2-(methylamino)ethoxy]ethoxy]propanoate |
| Molecular Formula | C12H25NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H25NO4/c1-12(2,3)17-11(14)5-7-15-9-10-16-8-6-13-4/h13H,5-10H2,1-4H3 |
| InChIKey | AVMNTSUPHZLJHS-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCNC |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
